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Uel Jackson McMahan

Professor
Neurobiology
Structural Biology

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Education/Training

Institution and Location Degree Year Field of Study
Westminster College, Fulton, MO B.A. 1956 - 1960 Biology
University of Tennessee Medical Units, Memphis, TN Ph.D. 1960 - 1964 Anatomy

Professional Experience:

1965-67
Instructor, Department of Anatomy, Yale University School of Medicine
1967-72

Principal Instructor, Department of Neurobiology, Harvard Medical School

1972-75

Assistant Professor, Department of Neurobiology, Harvard Medical School

1975-77

Associate Professor, Department of Neurobiology, Harvard Medical School

1977-
Professor of Neurobiology, Stanford University School of Medicine
1986-91
Chairman, Interdepartmental Neurosciences Ph.D. Program, Stanford University
1987-92
Chairman, Department of Neurobiology, Stanford University School of Medicine.
1989-90
Chairman, Committee on Graduate Studies, Stanford University
2002- Professor of Structural Biology, Stanford University School of Medicine
2003- Director of the Visiting Lecture Team Program for the International Brain Research Organization (IBRO-VLTP).
2004- Director of High Resolution Electron Microscope Facility for Biomedical Sciences, Stanford University School of Medicine

Short Courses

1977-83
Principal Instructor, Cold Spring Harbor Summer Course: The Synapse
1984

Principal Instructor, Stanford Summer Course: Cellular & Molecular Biol. of the Synapse

2000-04

Instructor, 2wk IBRO-VLTP Courses in Neuroscience: Nigeria, Cuba, Vietnam, Iran, Poland, Turkey, China, Costa Rica, Romania

2001-03

Lecturer, Summer Neurobiology Course, Marine Biology Laboratory, Woods Hole, MA.

   

Awards

1973-77
Research Career Development Award (NIH)
1984-91

Jacob Javits Neurosciences Investigator Award (NIH).

1991-98

Jacob Javits Neurosciences Investigator Award (NIH).

1996

Alumni Achievement Award, Westminster College, Fulton, MO.

1998

Fondation IPSEN/Fondation de France Prix (Plasticite Neuronale) shared with Dr. G. Fischbach (Harvard) and Dr. H. Betz (MPI, Frankfurt).

Publications

  • McMahan, U.J. A cytological analysis of interneuronal relationships in the dorsal nucleus of the lateral geniculate body of normal and experimental rats. Thesis, University of Tennessee Library, 1964.
  • McMahan, U.J. Fine structure of synapses in the dorsal nucleus of the lateral geniculate body of normal and blinded rats. Z. Zellforsch. 76:ll6-l46, 1967.
  • McMahan, U.J. and Kuffler, S.W. Viewing cholinergic synaptic areas on living nerve cells of the frog's heart. In: Excitatory Synaptic Mechanisms. Ed.: P. Andersen and J.K.S. Jansen, Universitetsforlaget, Oslo , pp. 57-66, 1970.
  • McMahan, U.J. and Kuffler, S.W. Visual identification of synaptic boutons on living ganglion cells and of varicosities in post-ganglionic axons in the heart of the frog. Proc. Roy. Soc. Lond. B. l77:485-508, 197l.
  • McMahan, U.J.and Spitzer, N.C. Viewing neuromuscular junctions in live, unstained skeletal muscle. J. Physiol. 2l6:35-37P, 197l.
  • McMahan, U.J. and Spitzer, N.C. and Peper, K. Visual identification of nerve terminals in living isolated skeletal muscle. Proc. Roy. Soc. Lond. B. l8l:42l-430, 1972.
  • Peper, K. and U.J.McMahan. Distribution of acetylcholine receptors in the vicinity of nerve terminals on skeletal muscle of the frog. Proc. Roy. Soc. Lond. B. l8l:43l-440, 1972.
  • McMahan, U.J. and Purves, D. An electron-microscopic study of a physiologically identified motoneurons in the leech C.N.S. after injection of the fluorescent dye procion yellow. J. Physiol. (Lond.) 222:64P, 1972.
  • Purves, D. and U.J.McMahan. The distribution of synapses on a physiologically identified motor neuron in the central nervous system of the medicinal leech: an electron microscope study after injection of the fluorescent dye Procion yellow. J. Cell Biol. 55:205-220, 1972.
  • Purves, D. and U.J.McMahan. Procion yellow as a marker for electron-microscopic examination of functionally identified nerve cells, In: Intracellular staining in Neurobiology . Ed. by Kater, S. and Nicholson, C. Springer-Verlag , New York , l2 pp, 1973.
  • Muller, K.J. and U.J.McMahan. Signalling in the nervous system: Synaptic morphology of specific neurons in the leech. Carnegie Institution Year Book 74, pp. 85-88, 1974.
  • McMahan, U.J. and Purves, D. Visual identification of two kinds of nerve cells and their synaptic contacts in a living autonomic ganglion of the mudpuppy (Necturus maculosus). J. Physiol. 254:405-426, 1976.
  • Roper, S., Purves, D. and U.J.McMahan. Synaptic organization and acetylcholine sensitivity of multiply innervated autonomic ganglion cells. Cold Spring Harbor Symp. Quant. Biol. XL, "The Synapse," 1976.
  • Muller, K.J. and U.J.McMahan. The shapes of sensory and motor neurones and the distribution of their synapses in ganglia of the leech: a study using intracellular injection of horseradish peroxidase. Proc. Roy. Soc. B. 194:48l-499, 1976.
  • Letinsky, M., Fischbeck, K.H., and U.J.McMahan. Precision of reinnervation of original postsynaptic sites in frog muscle after a nerve crush. J. Neurocytol. 5:69l-7l8, 1976.
  • Rotshenker, S. and U.J.McMahan. Altered patterns of innervation in frog muscle after denervation. J. Neurocytol. 5:719-750, 1976.
  • Marshall , L.M., Sanes, J.R. and U.J.McMahan. Reinnervation of original synaptic sites on muscle fiber basement membrane after disruption of the muscle cells. Proc. Natl. Acad. Sci. 74:3073-3077, 1977.
  • McMahan, U.J., Sanes, J.R. and Marshall , L.M. Cholinesterase is associated with the basal lamina at the neuromuscular junction. Nature 27l:l72-l74, 1977.
  • Sanes, J.R., Marshall , L.M. and U.J.McMahan. Reinnervation of muscle fiber basal lamina after removal of myofibers: Differentiation of regenerating axons at original synaptic sites. J. Cell Biol. 78:l76-198, 1978.
  • Burden, S.J., Sargent, P.B. and U.J.McMahan. Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve. J. Cell Biol. 82:412-425, 1979.
  • McMahan, U.J., Sargent, P.B., Rubin, L.L. and Burden, S.J. Factors that influence the organization of acetylcholine receptors in regenerating muscle are associated with the basal lamina at the neuromuscular junction, In: Ontogenesis and Functional Mechanisms of Peripheral Synapses. Ed. by Taxi, J., Elsevier/North Holland , Amsterdam , 345-354, 1980.
  • Sanes, J.R., Marshall , L.M. and U.J. McMahan, Reinnervation of skeletal muscle: restoration of the normal synaptic pattern. In: Nerve Repair and Regeneration , D.L. Jewett and H.R. McCarroll, Jr., Eds. C.V. Mosby Co., St. Louis, pp. l30-l38, 1980.
  • McMahan, U.J., Edgington, D.R. and Kuffler, D.P.: Factors that influence regeneration of the neuromuscular junction. J. Exp. Biol. 89:3l-42, 1980.
  • Rubin, L.L. and U.J. McMahan. Regeneration of the neuromuscular junction: steps toward defining the molecular basis of the interaction between nerve and muscle. In: Disorders of the Motor Unit , Ed. by D.L. Schotland, John Wiley and Sons, New York , 187-196, 1982.
  • Wallace, B.G., Godfrey, E.W., Nitkin, R.M., Rubin, L.L., and McMahan, U.J. An extract of extracellular matrix that organizes acetylcholine receptors. In: Muscle Development: Molecular and Cellular Control , edited by Mark Pearson and Henry Epstein, Cold Spring Harbor Laboratories, Cold Spring Harbor , New York , pp. 469-495, 1982.
  • Godfrey, E.W., Nitkin, R.M., Wallace, B.G. and McMahan, U.J. Identifying components of extracellular matrix that organize ACh receptors at synaptic sites on regenerating muscle cells. In: Developing and Regenerating Vertebrate Nervous Systems . Alan R. Liss, Inc., New York , pp. 6l-70, 1983.
  • Nitkin, R.M., Wallace, B.G., Spira , M.E. , Godfrey, E.W. and McMahan, U.J. Molecular components of the synaptic basal lamina that direct differentiation of regenerating neuromuscular junctions. Cold Spring Harbor Symposium , Quant. Biol. 48:653-665, 1983.
  • Nitkin, R.M., Fallon, J., Godfrey, E., Wallace, B.G. and McMahan, U.J. The role of extracellular matrix in regeneration of the neuromuscular junction. In: The Role of Extracellular Matrix in Development , ed. by R.L. Trelstad, Alan R. Liss, Inc., New York, pp. 598-622, 1984.
  • Anglister, L. and McMahan, U.J. Extracellular matrix components involved in neuromuscular transmission and regeneration. In: Basement Membranes and Cell Movement. Ciba Foundation Symposium l08. Pitman, New York , pp. l63-l78, 1984.
  • McMahan, U.J. and Slater, C.R. The influence of basal lamina on the accumulation of acetylcholine receptors at synaptic sites in regenerating muscles. J. Cell Biol. 98:l453-l473, 1984.
  • Godfrey, E.W., Nitkin, R.M., Wallace, B.G., Rubin, L.L., and McMahan, U.J. Components of Torpedo electric organ and muscle that cause aggregation of acetylcholine receptors on cultured muscle cells. J. Cell Biol. 99:6l5-627, 1984.
  • Fallon, J.R., Nitkin, R.M., Reist, N.E., Wallace, B.G. and McMahan, U.J. Acetylcholine receptor-aggregating factor is similar to molecules concentrated at neuromuscular junctions. Nature (Lond.). 3l 5:57 l-574, 1985.
  • Wallace, B.G., Nitkin, R.M., Reist, N.E., Fallon, J.R., Moayeri, N.N. and McMahan, U.J. Aggregates of acetylcholinesterase induced by acetylcholine receptor-aggregating factor. Nature (Lond.). 3l5:574-577, 1985.
  • Fallon, J.R., Nitkin, R.M., Wallace, B.G. and McMahan, U.J. Identifying the components of muscle fiber basal lamina that aggregate acetylcholine receptors at regenerating neuromuscular junctions. In: Molecular Bases of Neural Development, ed by Edelman, Gall, and Cowan. John Wiley & Sons, New York . pp. 6l-66. 1985.
  • Anglister, L. and McMahan, U.J. Basal lamina directs acetylcholinesterase accumulation at synaptic sites in regenerating muscle. J. Cell Biol. l0l:735-743, 1985.
  • Magill, C., Reist, N.E., Fallon, J.R., Nitkin, R.M., Wallace, B.G. and McMahan, U.J. Agrin. In: Progress in Brain Research Neural Regeneration , ed by Seil, Herbert and Carlson. Elsevier Science Publishers B.V., Biomedical Division, Amsterdam . pp. 351-396. 1987.
  • McMahan, U.J. and Wallace, B.G. Extracellular matrix. In: Encyclopedia of Neuroscience , ed by G. Adelman. Birkha;user Boston , Secaucus. 1987.
  • 38. Connor, E.A. and McMahan, U.J. Cell accumulation in the junctional region of denervated muscle. J. Cell Biol. 104:109-120, 1987.
  • 39. Smith, M.A., Yao , Y-M., Reist, N.E., Magill, C., Wallace, B.G. and McMahan, U.J. Identification of agrin in electric organ extracts and localization of agrin-like molecules in muscle and central nervous system. J. Exptl. Biol. l32:223-230, 1987.
  • Reist, N.E., Magill, C. and U.J. McMahan. Agrin-like molecules at synaptic sites in normal, damaged and denervated skeletal muscles. J. Cell Biol. 105:2457-2470, 1987.
  • Nitkin, R.M., Smith, M.A., Magill, C., Fallon, J.R., Yao , Y-M.M., Wallace, B.G., and U.J. McMahan. Identification of agrin, a synaptic organizing protein from Torpedo electric organ. J. Cell Biol. l05 :2471-2478, 1987.
  • Magill-Solc, Catherine and U.J. McMahan. Motor Neurons Contain Agrin-like Molecules. J. Cell Biol. 107:1825-1833, 1988.
  • Magill-Solc, C., Reist, N.E. and U.J. McMahan. Agrin-like molecules in synaptic basal lamina and in motor neurons. In: Molecular Neurobiology. Proceedings of the First NIMH Conference . ed. by S. Zaleman and R. Scheller, Department of Health and Human Services, ADAMHA, pgs. 100-109, 1989.
  • McMahan, U.J. and B.G. Wallace. Molecules in basal lamina that direct the formation of synaptic specializations at neuromuscular junctions. Dev. Neurosci. 11:227-247, 1989.
  • Magill-Solc, C. and U.J. McMahan. Agrin-like molecules in motor neurons. J. Physiol., Paris, 84:78-81, 1990.
  • Magill-Solc, C. and U.J. McMahan. Synthesis and transport of agrin-like molecules in motor neurons. J. Exptl. Biol. 153:1-10, 1990.
  • McMahan, U.J. The agrin hypothesis. Cold Spring Harbor Symp. Quant. Biol. 50:407-418, 1990.
  • Ruegg, M.A., Tsim, K.W.K., Horton, S.E., Kröger, S., Escher, G., Gensch, E.M. and U.J. McMahan. The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. Neuron 8:691-699, 1992.
  • Tsim, K.W.K, Ruegg, M.A., Escher, G., Kröger, S. and U.J. McMahan. cDNA that encodes active agrin. Neuron 8:677-689, 1992.
  • Reist, N.E., Werle, M.J. and U.J. McMahan. Agrin released by motor neurons induces the aggregation of AChRs at neuromuscular junctions. Neuron 8: 865-868, 1992.
  • Smith, M.A., Magill-Solc, C., Rupp F., Tao, M. Y.-M., Schilling, J.W., Snow, P., and U.J. Mahan 1992 Isolation and Characterization of a cDNA that encodes an agrin homolog in the marine ray. Mol. Cell. Neurosci. 3: 406-417, 1992.
  • McMahan, U.J., Horton, S.E., Werle, M.J., Honig, L.S., Kroger, S., Ruegg, M.A. and G. Escher. Agrin Isoforms and their role in synaptogenesis. Curr. Op. in Cell Biol. 4:869-874, 1992.
  • Anglister, L., Haessart, H. and U.J.McMahan. Globular and asymmetric acetylcholinesterase in the synaptic basal lamina at the neuromuscular junction of skeletal muscle. J. Cell Biol. 125:183-196, 1994.
  • Chang, H., Riese, D.J., Gilbert, W., Sterns, D. and U.J. McMahan. Ligands for ErbB- family receptors encoded by a neuregulin-like gene. Nature 387: 509-511, 1997.
  • Cohen, I. , Rimer, M., Lømo, T. and U.J. McMahan. Agrin-induced postsynaptic-like apparatus in vivo . Mol. Cell. Neurosci. 4:237-253, 1997.
  • Rimer, M., Mathiesen, I. , Lømo, T. and U.J. McMahan. γ-AChR/ ε-AChR switch at agrin-induced postsynaptic-like apparatus in skeletal muscle. Mol. Cell. N Neurosci . 4:254-263, 1997.
  • Rimer, M., Cohen, I. , Lømo, T., Burden, S.J. and U.J.McMahan. Neuregulin and erbB receptors at neuromuscular junctions and at agrin-induced postsynaptic-like apparatus in skeletal muscle. Mol. Cell. Neurosci. 12:1-15, 1998.
  • Harlow , M., Ress, D., Koster, A. Marshall, R.M., Schwarz, M. and U.J.McMahan. Dissection of active zones at the neuromuscular junction by EM tomography. J. Physiol ( Paris ) 92:75-78, 1998.
  • Mathiesen, I., Rimer, M., Ashtari, O., Cohen, I., McMahan, U.J. and Lømo, T., Regulation of the number, size and distribution of agrin-induced postsynaptic-like apparatus in adult skeletal muscle by electrical muscle activity. Mol. Cell. Neurosci. 13: 207-217, 1999.
  • Ress, D., Harlow , M.L., Schwarz, M., Marshall , R.M., and U.J. McMahan. Automatic acquisition of fiducial markers and alignment of images in tilt series for electron tomography. J. Electron Microscopy 48: 277-287, 1999.
  • Harlow , M.L., Ress, D., Stoschek, A., Marshall , R.M. and McMahan, U.J. The architecture of active zone material at the frog's neuromuscular junction. Nature 409: 479-484, 2001.
  • Ress, D., Harlow , M.L., Marshall , R.M. and U. J. McMahan. Optimization method for isodensity surface models obtained with electron microscope tomography data. Engineering in Medicine and Biology Society, 2003. Proceedings of the 25 th Annual Conference of the IEEE 1: 774-77, 2003.
  • Ress, D.B., Harlow, M.L., Marshall, R.M. and McMahan, U.J. Methods for generating high-resolution structural models from electron microscope tomography data. Structure : 12 (10):1763-1774, 2004.

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Last modified: 9/12/06